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. 2017 Feb 2;8:325-333.
doi: 10.3762/bjnano.8.35. eCollection 2017.

Selective Photodissociation of Tailored Molecular Tags as a Tool for Quantum Optics

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Free PMC article

Selective Photodissociation of Tailored Molecular Tags as a Tool for Quantum Optics

Ugur Sezer et al. Beilstein J Nanotechnol. .
Free PMC article

Abstract

Recent progress in synthetic chemistry and molecular quantum optics has enabled demonstrations of the quantum mechanical wave-particle duality for complex particles, with masses exceeding 10 kDa. Future experiments with even larger objects will require new optical preparation and manipulation methods that shall profit from the possibility to cleave a well-defined molecular tag from a larger parent molecule. Here we present the design and synthesis of two model compounds as well as evidence for the photoinduced beam depletion in high vacuum in one case.

Keywords: molecular quantum optics; photodepletion; photodissociation; synthetic photo-tags.

Figures

Figure 1
Figure 1
Sketch of the photocleavable 2-(phenoxymethyl)-1-nitrobenzene subunit and its intramolecular photon induced degradation sequence which leads to the release of the phenol subunit (red).
Scheme 1
Scheme 1
Synthesis of the trimeric target structure 1. Reagents and conditions: a) NaBH4, THF, 30 min, rt, quant.; b) 3,5-bis(trifluoromethyl)phenol, DIAD, Ph3P, THF, 12 h, rt, 96%; c) TMS-CC-H, Pd(PPh3)4, CuI, TEA, 90 °C, 12 h, 99%; d) TBAF (1 M in THF), CH2Cl2, rt, 30 min, quant.; e) 1,3,5-triiodobenzene, 5 (4.5 equiv), Pd(PPh3)4, CuI, THF/TEA (3:1), 12 h, 50 °C, 80%.
Figure 2
Figure 2
Qualitative photocleavage experiment of the monomer 4 irradiated at 355 nm inside the NMR spectrometer. The background displays the increase of the aldehyde signal of the 2-nitrosoaldehyde 6 with increasing light exposure.
Figure 3
Figure 3
Continuous illumination of the trimer 1 in dichloromethane solution by UV light of 254 nm (a) and 365 nm (b). The exponential decay (red line) of the molar extinction coefficient illustrates the phototriggered dissociation of the parent structure.
Figure 4
Figure 4
Molecular beam machine to study the photodepletion of the photoactive monomer in high vacuum. The pulsed infrared laser beam desorbs the molecules which are entrained by the adiabatically expanding neon gas jet. The neutral beam propagates for 75 cm in high vacuum before it is ionized by the pulsed radiation of a 157.6 nm F2 laser and analysed in a time-of-flight mass spectrometer. On the way to the detector the molecular beam is exposed to a collinear UV laser beam at 266 nm.
Figure 5
Figure 5
Photodepletion of the photocleavable nitrobenzyl derivative. When the dissociation laser pulse with an energy of 3.7(1) mJ in a beam diameter of 3.3(1) mm preceded the VUV ionization pulse by 600 µs, we observed beam depletion of the neutral parent molecule by a factor of four (red curve). The black spectrum represents the calibration curve without cleavage laser beam.
Figure 6
Figure 6
Depletion ratio, i.e., fraction of remaining parent molecules, versus laser fluence (photons per pulse and area). The continuous line is a fit to the data to derive the depletion cross section of the photoactive monomer.
Figure 7
Figure 7
Bond-selective dissociation and photoinduced beam depletion shall enable novel absorptive optical gratings for complex nanobiological materials, which cannot be handled by established optical manipulation techniques based on photoionization. The idea is here illustrated for a nitrobenzyl tagged virus (artist’s view).

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References

    1. Arndt M, Nairz O, Voss-Andreae J, Keller C, van der Zouw G, Zeilinger A. Nature. 1999;401:680–682. doi: 10.1038/44348. - DOI - PubMed
    1. Juffmann T. Surface based detection schemes for molecular matter-wave interferometry. Austria: University of Vienna; 2012.
    1. Tino G, Kasevich M. Proceedings of the International School of Physics "Enrico Fermi". Vol. 188. Amsterdam, The Netherlands: IOS Press; 2014. Atom Interferometry.
    1. Arndt M, Hornberger K. Nat Phys. 2014;10:271–277. doi: 10.1038/nphys2863. - DOI
    1. Arndt M, Juffmann T, Vedral V. HFSP J. 2009;3:386–400. doi: 10.2976/1.3244985. - DOI - PMC - PubMed

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