Magnesium sulfate in pediatric anesthesia: the Super Adjuvant

Paediatr Anaesth. 2017 May;27(5):480-489. doi: 10.1111/pan.13129. Epub 2017 Feb 28.


Magnesium is an essential chemical element in all organisms, intervening in most cellular enzymatic reactions; thus, its importance in homeostasis and as a therapeutic tool in highly challenging patients such as pediatrics. The primary purpose of this paper was to review the role of magnesium sulfate as an adjuvant drug in pediatric anesthesia. This compound already has the scientific backing in certain aspects such as analgesia or muscle relaxation, but only theoretical or empirical backing in others such as organ protection or inflammation, where it seems to be promising. The multitude of potential applications in pediatric anesthesia, its high safety, and low cost make magnesium sulfate could be considered a Super Adjuvant.

Keywords: anesthesia; child; magnesium; magnesium sulfate; pediatric anesthesia; pediatrics.

Publication types

  • Review

MeSH terms

  • Adjuvants, Anesthesia*
  • Adolescent
  • Analgesia
  • Analgesics
  • Anesthesia / methods*
  • Child
  • Child, Preschool
  • Humans
  • Infant
  • Infant, Newborn
  • Magnesium / physiology
  • Magnesium Sulfate*
  • Pediatrics / methods*


  • Adjuvants, Anesthesia
  • Analgesics
  • Magnesium Sulfate
  • Magnesium