Association of dietary vitamin E intake with risk of lung cancer: a dose-response meta-analysis

Asia Pac J Clin Nutr. 2017 Mar;26(2):271-277. doi: 10.6133/apjcn.032016.04.


Background and objectives: Several epidemiological studies investigating the association between dietary vitamin E intake and the risk of lung cancer have demonstrated inconsistent results. Hence, a meta-analysis was conducted to summarise evidence of the association of dietary vitamin E intake with the risk of lung cancer.

Methods and study design: In this meta-analysis, a systematic literature search of PubMed and Web of Science was conducted to identify relevant studies published from 1955 to April 2015. If p<0.05 or I2 >50%, a random effect model was used to estimate overall relative risks (RRs) and 95% confidence intervals (CIs). Otherwise, a fixed effect model was applied. Publication bias was estimated using the funnel plot and Egger's test. The doseresponse relationship was assessed using the method of restricted cubic splines with 4 knots at percentiles 5, 35, 65, and 95 of the distribution.

Results: The pooled RR of lung cancer for the highest versus lowest categories of dietary vitamin E intake was 0.84 (95% CI=0.76-0.93). With every 2 mg/d increase in dietary vitamin E intake, the risk of lung cancer statistically decreased by 5% (RR=0.95, 95% CI =0.91-0.99, plinearity=0.0237).

Conclusions: Our analysis suggests that higher dietary vitamin E intake exerts a protective effect against lung cancer.

Publication types

  • Meta-Analysis

MeSH terms

  • Diet*
  • Dose-Response Relationship, Drug
  • Humans
  • Lung Neoplasms / epidemiology
  • Lung Neoplasms / prevention & control*
  • Male
  • Risk
  • Vitamin E / administration & dosage*


  • Vitamin E