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Meta-Analysis
, 7 (2), e013981

Association Between Bipolar Spectrum Disorder and Bone Health: A Meta-Analysis and Systematic Review Protocol

Affiliations
Meta-Analysis

Association Between Bipolar Spectrum Disorder and Bone Health: A Meta-Analysis and Systematic Review Protocol

Vinoomika Chandrasekaran et al. BMJ Open.

Abstract

Introduction: Bipolar spectrum disorder is a chronic, episodic illness, associated with significant personal, social and economic burden. It is estimated to affect ∼2.4% of the population worldwide and is commonly associated with psychological and/or physiological comorbidities. Osteoporosis is one such comorbidity, a disease of bone that is asymptomatic until a fracture occurs. This systematic review attempts to capture, collate, assess and discuss the literature investigating the association between bipolar spectrum disorder and bone health.

Methods and analysis: We aim to identify articles that investigate the association between bipolar spectrum disorder and bone health in adults by systematically searching the MEDLINE, PubMed, OVID and CINAHL databases. Two independent reviewers will determine eligibility of studies according to predetermined criteria, and methodological quality will be assessed using a previously published scoring system. A meta-analysis will be conducted, and statistical methods will be used to identify and control for heterogeneity, if possible. If numerical syntheses are prevented due to statistical heterogeneity, a best evidence synthesis will be conducted to assess the level of evidence for associations between bipolar spectrum disorder and bone health.

Ethics and dissemination: Ethical permission will not be required for this systematic review since only published data will be used. This protocol will be registered with PROSPERO. Findings of the review will be published in a peer-reviewed scientific journal, and will be presented to clinical and population health audiences at national and international conferences.

Keywords: Bipolar Disorder; Bone Health; EPIDEMIOLOGY; Systematic Review Protocol.

Conflict of interest statement

Competing interests: SLB-O has received speaker fees from Amgen, and Grant/Research support from the University of Melbourne, Deakin University, Arthritis Victoria, Arthritis Australia, Australian Association of Gerontology, and the City of Greater Geelong. JAP has received speaker fees from Amgen, Eli Lilly and Sanofi-Aventis and funding from the Geelong Region Medical Research Foundation, Barwon Health, Perpetual Trustees, The University of Melbourne, Deakin University, ANZ Charitable Trust, the American Society for Bone and Mineral Research, Amgen (Europe) GmBH, the BUPA Foundation, Osteoporosis Australia, Australia and New Zealand Bone and Mineral Society and the NHMRC. MB has received Grant/Research Support from the NIH, Simons Foundation, CRC for Mental Health, Stanley Medical Research Institute, MBF, NHMRC, Beyond Blue, Geelong Medical Research Foundation, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Organon, Novartis, Mayne Pharma, Servier and Astra Zeneca, and he has been a paid consultant for Astra Zeneca, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Janssen Cilag, Lundbeck and Pfizer and a paid speaker for Astra Zeneca, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Janssen Cilag, Lundbeck, Organon, Pfizer, Sanofi Synthelabo, Solvay and Wyeth. LJW has received Grant/Research support from Eli Lilly, Pfizer, The University of Melbourne, Deakin University and the NHMRC.

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References

    1. Merikangas KR, Jin R, He JP et al. Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Arch Gen Psychiatry 2011;68:241–51. 10.1001/archgenpsychiatry.2011.12 - DOI - PMC - PubMed
    1. Murray CL, Lopez AD. Summary: global burden of disease. In: Global burden of disease and injury series. Boston, MA, USA: The harvard school of public health, on behalf of the world health organization and the world bank, 1996:20–7.
    1. Laxman KE, Lovibond KS, Hassan MK. Impact of bipolar disorder in employed populations. Am J Manag Care 2008;14:757–64. - PubMed
    1. Fajutrao L, Locklear J, Priaulx J et al. A systematic review of the evidence of the burden of bipolar disorder in Europe. Clin Pract Epidemiol Ment Health 2009;5:3–3. 10.1186/1745-0179-5-3 - DOI - PMC - PubMed
    1. Forty L, Ulanova A, Jones L et al. Comorbid medical illness in bipolar disorder. Br J Psychiatry 2014;205:465–72. 10.1192/bjp.bp.114.152249 - DOI - PMC - PubMed

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