A human retinoic acid receptor which belongs to the family of nuclear receptors

Nature. 1987 Dec 3-9;330(6147):444-50. doi: 10.1038/330444a0.

Abstract

A cDNA encoding a protein that binds retinoic acid with high affinity has been cloned. The protein is homologous to the receptors for steroid hormones, thyroid hormones and vitamin D3, and appears to be a retinoic acid-inducible trans-acting enhancer factor, suggesting that the molecular mechanisms of the effect of retinoids (vitamin A) on embryonic development, differentiation and tumour cell growth are similar to those described for other members of this nuclear receptor family.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Carrier Proteins / genetics*
  • Carrier Proteins / metabolism
  • Cell Nucleus / metabolism*
  • Chromosome Mapping
  • Cloning, Molecular
  • DNA / genetics
  • HeLa Cells
  • Humans
  • Molecular Sequence Data
  • Receptors, Retinoic Acid
  • Transcription, Genetic / drug effects
  • Transfection
  • Tretinoin / metabolism
  • Tretinoin / pharmacology

Substances

  • Carrier Proteins
  • Receptors, Retinoic Acid
  • Tretinoin
  • DNA

Associated data

  • GENBANK/X06538