Determination of Seroprevalence of Borrelia burgdorferi IgG in Adult Population Living in Trabzon

Balkan Med J. 2017 Jan;34(1):47-52. doi: 10.4274/balkanmedj.2015.0478. Epub 2017 Jan 5.

Abstract

Background: Lyme borreliosis is a tick-borne, multi-systemic infectious disease that is thought to be wide spread in Turkey even though studies on its seroprevalence are limited.

Aims: To determine the seroprevalence of Lyme borreliosis in part of north-eastern Tur-key (in the city of Trabzon), and to identify possible relationships between seropositivity and various factors such as location, gender, age group, occupation, income, and educational level.

Study design: Retrospective cross-sectional study.

Methods: A total of 884 blood samples collected from provincial and district health centers serving a population of about 800,000 were included in this study. ELISA was used to determine the anti-Borrelia IgG antibody levels in the samples. Samples that yielded positive results by ELISA were further subjected to western blot (WB).

Results: IgG antibodies were found in 128 samples (14.5%). Statistical analysis revealed significant differences between age groups and educational levels in terms of the incidence of seropositivity, whereas location, gender, occupational group and income level had no effect (p<0.001, p<0.001, p=0.948, p=0.645, p=0.131, p=0.080 respectively).

Conclusions: The risk of contracting Lyme borreliosis in Trabzon is high, and necessary measures need to be taken to avoid the spread of disease.

Keywords: ELISA; Lyme borreliosis; seroprevalence; tick; western blot.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Bacterial / analysis*
  • Antibodies, Bacterial / blood
  • Borrelia burgdorferi / immunology*
  • Cross-Sectional Studies
  • Enzyme-Linked Immunosorbent Assay / methods
  • Female
  • Humans
  • Immunoglobulin G / analysis
  • Immunoglobulin G / blood
  • Male
  • Middle Aged
  • Retrospective Studies
  • Seroepidemiologic Studies
  • Turkey

Substances

  • Antibodies, Bacterial
  • Immunoglobulin G