A novel human nonviral retroposon derived from an endogenous retrovirus

Nucleic Acids Res. 1987 Nov 11;15(21):8725-37. doi: 10.1093/nar/15.21.8725.


In a human genome, we found dispersed repetitive sequences homologous to part of a human endogenous retrovirus termed HERV-K which resembled mouse mammary tumor virus. For elucidation of their structure and organization, we cloned some of these sequences from a human gene library. The sequence common to the cloned DNA was ca. 630 base-pairs (bp) in length with an A-rich tail at the 3' end and was found to be a SINE (short interspersed repeated sequence) type nonviral retroposon. In this retroposon, the 5' end had multiple copies of a 40 bp direct repeat very rich in GC content and about the next 510 nucleotides were homologous to the 3' long terminal repeat and its upstream flanking region of the HERV-K genome. This retroposon was thus given the name, SINE-R element since most of it derived from a retrovirus. SINE-R elements were present at 4,000 to 5,000 copies per haploid human genome. The nucleotide sequence was ca. 90% homologous among the cloned elements.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA / analysis
  • DNA Transposable Elements*
  • DNA, Neoplasm / analysis
  • Genes, Viral*
  • Humans
  • Leukemia / genetics
  • Molecular Sequence Data
  • Repetitive Sequences, Nucleic Acid
  • Retroviridae / genetics*
  • Sequence Homology, Nucleic Acid


  • DNA Transposable Elements
  • DNA, Neoplasm
  • DNA

Associated data

  • GENBANK/X07417
  • GENBANK/X07418
  • GENBANK/X07419