Pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome: differential diagnosis of septic arthritis by regular detection of exceedingly high synovial cell counts

Infection. 2017 Aug;45(4):395-402. doi: 10.1007/s15010-017-0996-1. Epub 2017 Mar 1.

Abstract

Pyogenic arthritis, pyoderma gangrenosum and acne syndrome was diagnosed in a 42-year-old patient, after an unusual persistency of high synovial cell counts had been noticed. Clinical peculiarities and problems with diagnosing septic versus non-septic arthritis are discussed.

Keywords: Acne; Anakinra; Arthritis; Autoinflammatory; Canakinumab; Corticosteroids; Exercise induced; Il-1 blocking; PAPA syndrome; PSTPIP1; Pyoderma gangrenosum; Pyogenic; Septic; Synovial fluid cell counts; TNF alpha blocking.

Publication types

  • Review

MeSH terms

  • Acne Vulgaris / diagnosis*
  • Arthritis, Infectious / diagnosis*
  • Cell Count
  • Diagnosis, Differential
  • Humans
  • Pyoderma Gangrenosum / diagnosis*
  • Synovial Membrane / cytology*

Supplementary concepts

  • Pyogenic arthritis, pyoderma gangrenosum, and acne