Hypolipidaemic effect and mechanism of paprika seed oil on Sprague-Dawley rats

J Sci Food Agric. 2017 Sep;97(12):4242-4249. doi: 10.1002/jsfa.8300. Epub 2017 May 2.


Background: Details regarding the functional properties of paprika seed oil are relatively scarce. In this study the hypolipidaemic effects and mechanisms of paprika seed oil on Sprague-Dawley rats are explored, which may improve the usage of paprika seed source and provide a theoretical basis of paprika seed oil for the alleviation of hyperlipidaemia.

Results: In capsaicin and paprika seed oil (PSO) groups, total cholesterol (TC) and total triglyceride (TG) in serum and liver lipids of rats were significantly decreased (P < 0.05). The contents of serum HDL cholesterol were increased and the contents of serum LDL cholesterol were decreased (P < 0.05). Real-time PCR analyses revealed that the hepatic mRNA expression of fatty acid synthetase (FAS) is decreased and the expression levels of HSL is increased (P < 0.05). The mRNA expression of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) is decreased and the expression levels of low-density lipoprotein receptor (LDLR) is significantly improved (P < 0.05). The cholesterol 7-hydroxylase (CYP7A1) expression is regulated to control the cholesterol-to-bile acid transformation and cholesterol excretion is promoted. Capsaicin and unsaturated fatty acid PSO can activate and improve the mRNA expression of transient receptor potential vanilloid type-1 (TRPV1) and peroxisome proliferators-activated receptors (PPARα).

Conclusion: The hypolipidaemic effects of paprika seed oil (PSO) may be attributed to the inhibition of lipid synthesis via suppressing the expression of HMG-CoAR, CYP7A1 and FAS, meanwhile, promoting the metabolism and excretion of lipids via up-regulating the expression of LDLR, HSL, TRPV1 and PPARα. © 2017 Society of Chemical Industry.

Keywords: capsaicin; hyperlipidaemic rats; hypolipidaemic effects; mRNA expression; male SD rats; paprika seed oil.

MeSH terms

  • Animals
  • Capsicum / chemistry*
  • Capsicum / metabolism
  • Cholesterol / blood
  • Cholesterol 7-alpha-Hydroxylase / genetics
  • Cholesterol 7-alpha-Hydroxylase / metabolism
  • Humans
  • Hyperlipidemias / diet therapy*
  • Hyperlipidemias / genetics
  • Hyperlipidemias / metabolism
  • Hypolipidemic Agents / metabolism*
  • Liver / metabolism
  • Male
  • PPAR alpha / genetics
  • PPAR alpha / metabolism
  • Plant Oils / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, LDL / genetics
  • Receptors, LDL / metabolism
  • Seeds / metabolism
  • Triglycerides / blood


  • Hypolipidemic Agents
  • PPAR alpha
  • Plant Oils
  • Receptors, LDL
  • Triglycerides
  • Cholesterol
  • Cholesterol 7-alpha-Hydroxylase