Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes

Proc Natl Acad Sci U S A. 1987 Dec;84(23):8535-9. doi: 10.1073/pnas.84.23.8535.


The tumor necrosis factor (TNF) alpha and beta gene pair has been linked in the human major histocompatibility complex to HLA-B, HLA-C, and, tentatively, HLA-E and HLA-A on one side and to the class III complement/steroid 21-hydroxylase gene cluster on the other by pulsed-field gel electrophoresis. The TNF genes are located 200 kilobases (kb) centromeric of HLA-B and about 350 kb telomeric of the class III cluster. Together with previous data on the linkage and structures of the class II and class III regions, a restriction map of the entire human major histocompatibility complex of about 3500 kb has been prepared.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping*
  • Chromosomes, Human, Pair 6*
  • Complement System Proteins / genetics*
  • DNA Restriction Enzymes
  • Genetic Linkage*
  • HLA Antigens / genetics*
  • HLA-D Antigens / genetics*
  • Humans
  • Major Histocompatibility Complex*
  • Tumor Necrosis Factor-alpha / genetics*


  • HLA Antigens
  • HLA-D Antigens
  • Tumor Necrosis Factor-alpha
  • Complement System Proteins
  • DNA Restriction Enzymes