Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis

PLoS One. 2017 Mar 2;12(3):e0172092. doi: 10.1371/journal.pone.0172092. eCollection 2017.

Abstract

Purpose: To discern and confirm genetic biomarkers that help identify populations at high risk for age-related cataract (ARC).

Methods: A literature search was performed in the PubMed, Web of Science and China National Knowledge Internet databases for genetic association studies published before June 26, 2016 regarding ARC susceptibility. All genetic polymorphisms reported were systematically reviewed, followed by extraction of candidate genes/loci with sufficient genotype data in ≥3 studies for the meta-analysis. A random/fixed-effects model was used to calculate the pooled odds ratios and 95% confidence intervals to evaluate the associations considering multiple genetic models. Sensitivity analysis was also performed.

Results: A total of 144 polymorphisms in 36 genes were reported in the 61 previous genetic association studies. Thereby, three polymorphisms of two genes (8-oxoguanine DNA glycosylase-1 [OGG1]; methylenetetrahydrofolate reductase NADPH [MTHFR]) in eight studies were included in the meta-analysis. Regarding the OGG1-rs1052133, the GG (OR = 1.925; 95%CI, 1.181-3.136; p = 0.009) and CG (OR = 1.384; 95%CI, 1.171-1.636; p<0.001) genotypes indicated higher risk of ARC. For the MTHFR gene, the CC+TT genotype of rs1801133 might be protective (OR, 0.838; 95%CI, 0.710-0.989; p = 0.036), whereas the AA+CC genotype of rs1801131 indicated increased risk for the mixed subtype (OR = 1.517; 95%CI, 1.113-2.067; p = 0.008).

Conclusions: Polymorphisms of OGG1 and MTHFR genes are associated with ARC susceptibility and may help identify populations at high risk for ARC.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Cataract / enzymology*
  • Cataract / genetics*
  • DNA Glycosylases / genetics*
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
  • Polymorphism, Genetic*

Substances

  • Methylenetetrahydrofolate Reductase (NADPH2)
  • DNA Glycosylases
  • oxoguanine glycosylase 1, human

Grants and funding

This study was supported by the Ministry of Science and Technology of China Grants (973 program, 2015CB964600)-YL, the Key Projects for Hospital Clinical Disciplines of the Ministry of Health of China in 2010-2012 (Project No. 175 in Document 439 of the Planning and Finance Secretary of the Ministry of Health)-YL, the Key Research Plan for the National Natural Science Foundation of China in Cultivation Project (No.91546101)-YL, the Outstanding Young Teacher Cultivation Projects in Guangdong Province(No.YQ2015006)-HL, Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund (the second phase)-HL, the clinical research and translational medical center of pediatric cataract in Guangzhou city, the Pearl River Science and Technology New Star (Grant No. 2014J2200060)-HL, Project of Guangzhou City, the Guangdong Provincial Natural Science Foundation for Distinguished Young Scholars of China (Grant No. 2014A030306030)-HL, the Youth Science and Technology Innovation Talents Funds in a Special Support Plan for High Level Talents in Guangdong Province (Grant No. 2014TQ01R573)-HL, the Science and Technology Program of Guangdong Province (Grant No. 2013B020400003)-HL, the Young Teacher Top-Support project of Sun Yat-sen University (Grant No. 2015ykzd11)-HL and Fundamental Research Funds of the State Key Laboratory of Ophthalmology (Grant No. 2015QN01)-HL. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.