Osteopontin splice variants and polymorphisms in cancer progression and prognosis

Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):93-108.A. doi: 10.1016/j.bbcan.2017.02.005. Epub 2017 Feb 28.


Osteopontin (OPN) is an extracellular matrix protein that is overexpressed in various cancers and promotes oncogenic features including cell proliferation, survival, migration, and angiogenesis, among others. OPN can participate in the regulation of the tumor microenvironment, affecting both cancer and neighboring cells. Here, we review the roles of OPN splice variants (a, b, c) in cancer development, progression, and prognosis, and also discuss the identities of isoforms 4 and 5. We also discussed how single-nucleotide polymorphisms (SNPs) of the OPN gene are an additional factor influencing the level of OPN in individuals, modulating the risks of cancer development and outcome.

Keywords: Alternative splicing isoforms; Malignancy; Prognosis; Single nucleotide polymorphisms (SNPs); Spp1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Disease Progression
  • Humans
  • Neoplasms / genetics*
  • Neoplasms / pathology*
  • Osteopontin / genetics*
  • Polymorphism, Genetic / genetics*
  • Prognosis
  • RNA Splicing / genetics*


  • Osteopontin