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. 2017 Aug;58(8):1314-1317.
doi: 10.2967/jnumed.116.185835. Epub 2017 Mar 2.

Resting-State Networks as Simultaneously Measured With Functional MRI and PET

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Free PMC article

Resting-State Networks as Simultaneously Measured With Functional MRI and PET

Alexandre Savio et al. J Nucl Med. .
Free PMC article

Abstract

Functional MRI (fMRI) studies reported disruption of resting-state networks (RSNs) in several neuropsychiatric disorders. PET with 18F-FDG captures neuronal activity that is in steady state at a longer time span and is less dependent on neurovascular coupling. Methods: In the present study, we aimed to identify RSNs in 18F-FDG PET data and compare their spatial pattern with those obtained from simultaneously acquired resting-state fMRI data in 22 middle-aged healthy subjects. Results: Thirteen and 17 meaningful RSNs could be identified in PET and fMRI data, respectively. Spatial overlap was fair to moderate for the default mode, left central executive, primary and secondary visual, sensorimotor, cerebellar, and auditory networks. Despite recording different aspects of neural activity, similar RSNs were detected by both imaging modalities. Conclusion: The results argue for the common neural substrate of RSNs and encourage testing of the clinical utility of resting-state connectivity in PET data.

Keywords: brain connectivity; glucose metabolism; independent component analysis; multimodal imaging; positron emission tomography.

Figures

FIGURE 1.
FIGURE 1.
Matched RSNs in fMRI and PET data with corresponding Dice coefficients: primary visual posterior (A), DMN (B), primary visual (posterior) (C), sensorimotor (D), secondary visual (E), cerebellar (F), central executive right (G), auditory (H), executive control (I), central executive left (J). Because right and left CENs were captured as 1 independent component in PET data, G and J for PET are the same.
FIGURE 2.
FIGURE 2.
Unmatched (unique to either fMRI or PET data) RSNs and noise components: salience (A), spatial attention (B), primary visual (anterior) (C), anterior insular (D), temporopolar (E), lateral motor (F), (anterior) default mode (G), basal ganglia (H), nucleus accumbens (I), secondary visual (J), mesial parietal/prefrontal (K).

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