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Comment
. 2017 Mar 2;20(3):300-301.
doi: 10.1016/j.stem.2017.02.010.

Bringing a Leukemic Stem Cell Gene Signature Into Clinics: Are We There Yet?

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Bringing a Leukemic Stem Cell Gene Signature Into Clinics: Are We There Yet?

Guillaume Richard-Carpentier et al. Cell Stem Cell. .

Abstract

Prognostic markers that capture leukemia stem cell (LSC) activity can be useful for the risk stratification of acute myeloid leukemia (AML) patients. In a recent issue of Nature, Ng et al. (2016) develop a prognostic score based on a 17-gene expression signature of LSCs to predict outcome in AML patients.

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  • A 17-gene stemness score for rapid determination of risk in acute leukaemia.
    Ng SW, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, Arruda A, Popescu A, Gupta V, Schimmer AD, Schuh AC, Yee KW, Bullinger L, Herold T, Görlich D, Büchner T, Hiddemann W, Berdel WE, Wörmann B, Cheok M, Preudhomme C, Dombret H, Metzeler K, Buske C, Löwenberg B, Valk PJ, Zandstra PW, Minden MD, Dick JE, Wang JC. Ng SW, et al. Nature. 2016 Dec 15;540(7633):433-437. doi: 10.1038/nature20598. Epub 2016 Dec 7. Nature. 2016. PMID: 27926740

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