Bringing a Leukemic Stem Cell Gene Signature into Clinics: Are We There Yet?

Cell Stem Cell. 2017 Mar 2;20(3):300-301. doi: 10.1016/j.stem.2017.02.010.


Prognostic markers that capture leukemia stem cell (LSC) activity can be useful for the risk stratification of acute myeloid leukemia (AML) patients. In a recent issue of Nature, Ng et al. (2016) develop a prognostic score based on a 17-gene expression signature of LSCs to predict outcome in AML patients.

Publication types

  • Comment

MeSH terms

  • Acute Disease
  • Humans
  • Leukemia, Myeloid, Acute / genetics*
  • Neoplastic Stem Cells*
  • Transcriptome