Progressing MoodSwings. The upgrade and evaluation of MoodSwings 2.0: An online intervention for bipolar disorder

Contemp Clin Trials. 2017 May;56:18-24. doi: 10.1016/j.cct.2017.02.008. Epub 2017 Feb 28.


MoodSwings 2.0 is a self-guided online intervention for bipolar disorder. The intervention incorporates technological improvements on an earlier validated version of the intervention (MoodSwings 1.0). The previous MoodSwings trial provides this study with a unique opportunity to progress previous work, whilst being able to take into consideration lesson learnt, and technological enhancements. The structure and technology of MoodSwings 2.0 are described and the relevance to other online health interventions is highlighted. An international team from Australia and the US updated and improved the programs content pursuant to changes in DSM-5, added multimedia components and included larger numbers of participants in the group discussion boards. Greater methodological rigour in this trial includes an attention control condition, quarterly telephone assessments, and red flag alerts for significant clinical change. This paper outlines these improvements, including additional security and safety measures. A 3 arm RCT is currently evaluating the enhanced program to assess the efficacy of MS 2.0; the primary outcome is change in depressive and manic symptoms. To our knowledge this is the first randomized controlled online bipolar study with a discussion board attention control and meets the key methodological criteria for online interventions.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Affect / physiology*
  • Aged
  • Antipsychotic Agents / therapeutic use
  • Australia
  • Bipolar Disorder / therapy*
  • Computer Security / standards
  • Female
  • Humans
  • Internet*
  • Male
  • Medication Adherence
  • Middle Aged
  • Motivation
  • Patient Safety
  • Quality of Life
  • Research Design
  • Self Care / methods*
  • Social Stigma
  • Social Support
  • Socioeconomic Factors
  • Therapy, Computer-Assisted / methods*
  • Therapy, Computer-Assisted / standards
  • United States
  • Young Adult


  • Antipsychotic Agents