Mitochondrial composition and function under the control of hypoxia

Redox Biol. 2017 Aug;12:208-215. doi: 10.1016/j.redox.2017.02.012. Epub 2017 Feb 24.

Abstract

Hypoxia triggers several mechanisms to adapt cells to a low oxygen environment. Mitochondria are major consumers of oxygen and a potential source of reactive oxygen species (ROS). In response to hypoxia they exchange or modify distinct subunits of the respiratory chain and adjust their metabolism, especially lowering the citric acid cycle. Intermediates of the citric acid cycle participate in regulating hypoxia inducible factors (HIF), the key mediators of adaptation to hypoxia. Here we summarize how hypoxia conditions mitochondria with consequences for ROS-production and the HIF-pathway.

Keywords: HIF; Hypoxia; Mitochondria; ROS; Respiratory chain.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Physiological
  • Animals
  • Cell Hypoxia
  • Humans
  • Hypoxia / metabolism*
  • Hypoxia-Inducible Factor 1 / metabolism
  • Mitochondria / metabolism*
  • Mitochondria / pathology
  • Reactive Oxygen Species / metabolism
  • Signal Transduction

Substances

  • Hypoxia-Inducible Factor 1
  • Reactive Oxygen Species