Possible Interventions to Modify Aging

Biochemistry (Mosc). 2016 Dec;81(12):1413-1428. doi: 10.1134/S0006297916120038.


The programmed aging paradigm interprets aging as a function favored by natural selection at a supra-individual level. This function is implemented, according to the telomere theory, through mechanisms that operate through the subtelomere-telomere-telomerase system. After reviewing some necessary technical and ethical reservations and providing a concise description of aging mechanisms, this work considers interventions that could lead to the control of some highly disabling characteristics of aging, such as Alzheimer's and Parkinson's syndromes and age-related macular degeneration, and afterwards to a full control of aging up to a condition equivalent to that of the species defined as "with negligible senescence". The various steps needed for the development of such interventions are described along general lines.

MeSH terms

  • Aging / genetics*
  • Animals
  • Cellular Senescence
  • Humans
  • Models, Biological
  • Primary Prevention
  • Telomerase / physiology
  • Telomere / genetics
  • Telomere Homeostasis


  • Telomerase