Incidence and Patient Outcomes in Renal Replacement Therapy After Orthotopic Liver Transplant

Exp Clin Transplant. 2017 Feb;15(Suppl 1):258-260. doi: 10.6002/ect.mesot2016.P126.


Objectives: Our objective was to evaluate the incidence of renal replacement therapy after orthotopic liver transplant and to evaluate and analyze patient outcomes.

Materials and methods: We performed a retrospective analysis of 177 consecutive patients at a tertiary care unit who underwent orthotopic liver transplant between January 2010 and June 2016. Patients who were admitted to the intensive care unit after orthotopic liver transplant and who required renal replacement therapy were included.

Results: A total of 177 (79 adult, 98 pediatric) orthotopic liver transplants were performed during the study period. Of these, 35 patients (19%) required renal replacement therapy during the early posttransplantation period. After excluding 5 patients with previous chronic renal failure, 30 patients (17%; 20 adult [25% ], 10 pediatric [10% ]) with acute kidney injury required renal replacement therapy. The mean patient age was 31.1 ± 20.0 years, with a mean Model for End-stage Liver Disease score of 16.7 ± 12.3. Of the patients with acute kidney injury who underwent renal replacement therapy, in-hospital mortality was 23.3% (7 of 30 patients), and 40% remained on dialysis. No significant difference was seen in mortality between early versus delayed initiation of renal replacement therapy in patients with stage 3 acute kidney injury (P = .17).

Conclusions: Of liver transplant recipients who present with acute kidney injury, 19% require renal replacement therapy, and in-hospital mortality is 20% in the early postoperative period.

MeSH terms

  • Acute Kidney Injury / diagnosis
  • Acute Kidney Injury / epidemiology*
  • Acute Kidney Injury / mortality
  • Acute Kidney Injury / therapy*
  • Adolescent
  • Adult
  • Child
  • Female
  • Hospital Mortality
  • Humans
  • Incidence
  • Liver Transplantation / adverse effects*
  • Liver Transplantation / mortality
  • Male
  • Middle Aged
  • Renal Replacement Therapy* / adverse effects
  • Renal Replacement Therapy* / mortality
  • Retrospective Studies
  • Risk Factors
  • Tertiary Care Centers
  • Time Factors
  • Treatment Outcome
  • Turkey / epidemiology
  • Young Adult