The efficacy of acupuncture on menopausal symptoms (ACOM study): protocol for a randomised study

Dan Med J. 2017 Mar;64(3):A5344.


Introduction: Around 75% of menopausal women experience hot flushes (HF) and 10-20% of all postmenopausal women find this very distressing. The aim of this study is to evaluate the efficacy of acupuncture on moderate-to-severe menopausal symptoms in general and HF in particular.

Methods: An un-blinded randomised trial (cross-over) with 1:1 allocation to early (intervention) versus late (control) acupuncture. The included women suffer from moderate-to-severe HF and will receive a weekly treatment during five consecutive weeks in the following predefined acupuncture points: CV-3, CV-4, LR-8, SP-6, SP-9. All acupuncturists will be medical doctors educated in acupuncture. The primary outcome is change in HF from baseline to week 6 measured by the HF scale from the MenoScores Questionnaire (MSQ). Secondary outcomes are change in other menopausal symptoms, in particular day and night sweats and menopausal-specific sleeping problems, also measured by other scales from the MSQ. A total of 68 patients must be enrolled to detect a relevant clinical reduction on the above MSQ scales. Both intention-to-treat and per-protocol analyses will be conducted; four or more treatments are considered adequate adherence.

Conclusions: In the ACOM study, we explore the potential benefits of acupuncture on moderate-to-severe meno-pausal symptoms. The cross-over design offers the possi-bility of examining the legacy effect of acupuncture.

Funding: The Idella Foundation, the University of Copenhagen and the Research Foundation of General Practice.

Trial registration: Clinicaltrials NCT02746497.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acupuncture Therapy / methods*
  • Adult
  • Cross-Over Studies
  • Denmark
  • Female
  • Hot Flashes / psychology
  • Hot Flashes / therapy*
  • Humans
  • Menopause* / physiology
  • Menopause* / psychology
  • Middle Aged
  • Quality of Life
  • Surveys and Questionnaires

Associated data