Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Oct;6(10):2953-7.

Physical Linkage of Three CD3 Genes on Human Chromosome 11

Affiliations
Free PMC article

Physical Linkage of Three CD3 Genes on Human Chromosome 11

A Tunnacliffe et al. EMBO J. .
Free PMC article

Abstract

T-cell antigen receptors are associated on T cell surfaces with a complex of proteins called CD3 (formerly T3). Human CD3 consists of at least four proteins, gamma, delta, epsilon and zeta, and all but the latter have been cloned as cDNA. Using standard cloning techniques, together with field inversion gel electrophoresis, we have demonstrated the physical linkage of three CD3 genes. The genes for CD3 gamma and CD3 delta are situated close together, about 1.6 kb apart, organized in a head-to-head orientation. The gene encoding CD3 gamma has been sequenced, and is split into seven exons spread over 9 kb of DNA. Like CD3 delta, CD3 gamma gene has an unusual promoter which lacks a TATA-box and potential Sp1 binding sites. The CD3 gamma-CD3 delta gene pair is within 300 kb of the CD3 epsilon gene, and therefore these genes form a tightly linked cluster in chromosome 11 band q23. The clustering of the CD3 genes may be significant in terms of their simultaneous activation during T-cell development.

Similar articles

See all similar articles

Cited by 23 articles

See all "Cited by" articles

References

    1. Int J Cancer. 1973 May;11(3):499-520 - PubMed
    1. Mol Cell Biol. 1986 Feb;6(2):365-71 - PubMed
    1. Int J Cancer. 1977 May 15;19(5):621-6 - PubMed
    1. Methods Enzymol. 1980;65(1):718-49 - PubMed
    1. Mol Cell Biol. 1986 Sep;6(9):3134-43 - PubMed

Publication types

LinkOut - more resources

Feedback