JA-Ile-macrolactones uncouple growth and defense in wild tobacco

Org Biomol Chem. 2017 Apr 18;15(16):3391-3395. doi: 10.1039/c7ob00249a.

Abstract

Small molecules capable of uncoupling growth-defense in plants are currently not known. In this study, for the first time, semi-synthetic analogues of the phytohormone JA-Ile are employed to uncouple growth and defense responses in wild tobacco. The JA-Ile analogues are easily synthesized from inexpensive substrates via olefin metathesis.

MeSH terms

  • Alkenes / chemistry
  • Cyclopentanes / chemical synthesis
  • Cyclopentanes / chemistry*
  • Cyclopentanes / pharmacology*
  • Isoleucine / analogs & derivatives*
  • Isoleucine / chemical synthesis
  • Isoleucine / chemistry
  • Isoleucine / pharmacology
  • Lactones / chemistry*
  • Nicotiana / drug effects*
  • Nicotiana / growth & development*
  • Nicotiana / immunology

Substances

  • Alkenes
  • Cyclopentanes
  • Lactones
  • jasmonoyl-isoleucine
  • Isoleucine