Recombinant human interleukin 5 is a selective activator of human eosinophil function

A F Lopez; C J Sanderson; J R Gamble; H D Campbell; I G Young; M A Vadas

doi:10.1084/jem.167.1.219

Recombinant human interleukin 5 is a selective activator of human eosinophil function

J Exp Med. 1988 Jan 1;167(1):219-24. doi: 10.1084/jem.167.1.219.

Authors

A F Lopez¹, C J Sanderson, J R Gamble, H D Campbell, I G Young, M A Vadas

Affiliation

¹ Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.

Abstract

Human rIL-5 was found to selectively stimulate morphological changes and the function of human eosinophils. This molecule is thus a prime candidate for the selective eosinophilia and eosinophil activation seen in disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Eosinophils / drug effects*
Eosinophils / physiology
Eosinophils / ultrastructure
Humans
Interleukin-5
Interleukins / pharmacology*
Neutrophils / drug effects
Recombinant Proteins / pharmacology
Superoxides / biosynthesis

Substances

Interleukin-5
Interleukins
Recombinant Proteins
Superoxides