The how, why and clinical importance of stratum corneum acidification

Exp Dermatol. 2017 Nov;26(11):999-1003. doi: 10.1111/exd.13329. Epub 2017 May 12.


In this article, I review the multiple endogenous mechanisms that contribute to the highly acidic pH of normal stratum corneum (SC). Then, I describe how each mechanism potentially impacts specific defensive functions of the SC. Finally, I review the rapidly expanding, clinical implications and potential therapeutic applications of SC acidification.

Keywords: pH; acidification; barrier function; stratum corneum.

Publication types

  • Review

MeSH terms

  • Epidermis / chemistry*
  • Epidermis / metabolism*
  • Epidermis / physiology
  • Humans
  • Hydrogen-Ion Concentration
  • Skin Diseases / physiopathology
  • Skin Physiological Phenomena