Designing repeat proteins: a modular approach to protein design

Curr Opin Struct Biol. 2017 Aug:45:116-123. doi: 10.1016/ Epub 2017 Mar 3.


Repeat proteins present unique opportunities for engineering because of their modular nature that potentially allows LEGO® like construction of macromolecules. Nature takes advantage of these properties and uses this type of scaffold for recognition, structure, and even signaling purposes. In recent years, new protein modeling tools facilitated the design of novel repeat proteins, creating possibilities beyond naturally occurring scaffolds alone. We highlight here the different design strategies and summarize the various structural families and novel proteins achieved.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Drug Design*
  • Humans
  • Protein Engineering / methods*
  • Proteins / chemistry*
  • Proteins / genetics*
  • Proteins / metabolism
  • Repetitive Sequences, Amino Acid*


  • Proteins