Analysis of the skin of mice humanized for the immune system

Exp Dermatol. 2017 Oct;26(10):963-966. doi: 10.1111/exd.13340. Epub 2017 Apr 10.


Development of new immunotherapeutic strategies relies on the ability to activate the right cells at the right place and at the right moment and on the capacity of these cells to home to the right organ(s). Skin delivery has shown high potency for immunotherapeutic administration. However, an adequate in vivo model of human skin immunity is still a critical bottleneck. We demonstrated here that the skin of human immune system mice is colonized by human hematopoietic cells, mainly human T cells and that complementation with human antigen-presenting cells at the vaccination site allowed the induction of an immune response.

Keywords: antigen-presenting cells; human immune system mice; intra-dermal vaccination; route of administration; skin T cells.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD34 / metabolism
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Dendritic Cells / immunology
  • HLA-A2 Antigen / genetics*
  • HLA-A2 Antigen / metabolism
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cells / metabolism*
  • Humans
  • Leukocyte Common Antigens / metabolism
  • Mice
  • Mice, Transgenic
  • Models, Animal*
  • Skin / cytology*
  • Skin / immunology*
  • Transplantation, Heterologous


  • Antigens, CD34
  • HLA-A2 Antigen
  • Leukocyte Common Antigens
  • PTPRC protein, human