Epstein-Barr virus related lymphoepithelioma-like carcinoma of lung

J Surg Oncol. 1987 Dec;36(4):280-3. doi: 10.1002/jso.2930360413.


A malignant neoplasm localized to the lung is reported in a rather unusual host: a 40-year-old female, nonsmoker, of South-East Asiatic origin. The histology was of nasopharyngeal-like carcinoma character and ultrastructural examination confirmed a diagnosis of nonkeratinizing, poorly differentiated squamous cell carcinoma. The clinicopathologic findings were more suggestive of a primary pulmonary origin than the manifestation of an occult nasopharyngeal primary. The immunological profile was highly suggestive of an Epstein-Barr virus (EBV) associated epithelial neoplasia. This case might widen the spectrum of EBV-associated neoplasia, by inclusion of lower respiratory tract as a target organ.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Burkitt Lymphoma / complications*
  • Carcinoma, Squamous Cell / complications
  • Carcinoma, Squamous Cell / pathology*
  • Carcinoma, Squamous Cell / physiopathology
  • Female
  • Herpesvirus 4, Human / isolation & purification
  • Humans
  • Lung Neoplasms / complications
  • Lung Neoplasms / pathology*
  • Lung Neoplasms / physiopathology