In vitro selection of random peptides against artificial lipid bilayers: a potential tool to immobilize molecules on membranes

Chem Commun (Camb). 2017 Mar 25;53(24):3458-3461. doi: 10.1039/c7cc00099e. Epub 2017 Mar 8.


The first in vitro selection of binding peptides against artificial lipid membranes from a random peptide library using an in vitro display method (cDNA display) is reported. The selected peptide, LB-1, has both amphiphilic and cationic regions, and proteins fused to LB-1 can be immobilized on the liposome surface.

MeSH terms

  • Amino Acid Sequence
  • DNA, Complementary / chemistry
  • DNA, Complementary / metabolism
  • Lipid Bilayers / chemistry
  • Lipid Bilayers / metabolism*
  • Liposomes / chemistry
  • Liposomes / metabolism
  • Microscopy, Confocal
  • Peptides / chemistry
  • Peptides / metabolism*
  • Polymerase Chain Reaction
  • Surface Plasmon Resonance


  • DNA, Complementary
  • Lipid Bilayers
  • Liposomes
  • Peptides