Update on endometriosis pathogenesis

Minerva Ginecol. 2017 Oct;69(5):447-461. doi: 10.23736/S0026-4784.17.04048-5. Epub 2017 Mar 7.


Endometriosis is a chronic, inflammatory, condition of high incidence and serious reproductive and general health consequences. Understanding the pathogenesis of endometriosis is crucial for proper diagnostic and ordering the most effective treatment. Even though there is a large body of data regarding this pathology our understanding of the pathogenesis of this disease remains incomplete. The aim of this review is to summarize contemporary data regarding pathogenesis of endometriosis. Current data regarding endometrial origin, metaplastic and Mullerian embryonic rests theory will be reviewed here. Also genetic, epigenetic, environmental factors and immunological dysfunction role in endometriosis will be summarized. To conclude, a lot of effort must be put to integrate the abundant data from genetic, epigenetic and immunological studies to propose one coherent theory for the pathogenesis of endometriosis.

Publication types

  • Review

MeSH terms

  • Endometriosis / diagnosis
  • Endometriosis / etiology
  • Endometriosis / pathology*
  • Epigenesis, Genetic*
  • Female
  • Humans
  • Mullerian Ducts*
  • Risk Factors