Simultaneous inference for semiparametric mixed-effects joint models with skew distribution and covariate measurement error for longitudinal competing risks data analysis

J Biopharm Stat. 2017;27(6):1009-1027. doi: 10.1080/10543406.2017.1293080. Epub 2017 Mar 28.

Abstract

Semiparametric mixed-effects joint models are flexible for modeling complex longitudinal-competing risks data. Skew distributions are commonly observed for this type of data. Covariates in the joint models are usually measured with substantial errors. We propose a Bayesian method for semiparametric mixed-effects joint models with covariate measurement errors and skew distribution. The methods are illustrated with AIDS clinical data. Simulation results are conducted to validate the proposed methods.

Keywords: Bayesian inference; competing risks; longitudinal data; measurement error; partially linear mixed-effects models; proportional hazard models; skew distribution; survival data.

MeSH terms

  • Acquired Immunodeficiency Syndrome / epidemiology
  • Bayes Theorem
  • Cohort Studies
  • Data Interpretation, Statistical*
  • Humans
  • Longitudinal Studies
  • Models, Statistical*
  • Multicenter Studies as Topic / methods
  • Multicenter Studies as Topic / statistics & numerical data*
  • Prospective Studies
  • Research Design / statistics & numerical data*
  • Risk Factors