Demodex and rosacea revisited

Clin Dermatol. 2017 Mar-Apr;35(2):195-200. doi: 10.1016/j.clindermatol.2016.10.014. Epub 2016 Oct 27.

Abstract

Demodex mites are part of the vast microbiome living on and within human skin. The interaction of the various microorganisms with the skin plays a key role in the maintenance of homeostasis. The precise role and function of Demodex mites within normal and diseased human skin remains elusive. The emergence of ivermectin as a key therapy for rosacea has refocused interest in the role of Demodex mites in the pathogenesis of this skin disease and the ability of Demodex to modulate the host immune system.

MeSH terms

  • Animals
  • Antiparasitic Agents / therapeutic use
  • Humans
  • Ivermectin / therapeutic use
  • Mites / physiology*
  • Rosacea / drug therapy*
  • Rosacea / parasitology*
  • Skin / parasitology

Substances

  • Antiparasitic Agents
  • Ivermectin