First assessment of simultaneous dual isotope ( 123 I/ 99m Tc) cardiac SPECT on two different CZT cameras: A phantom study

J Nucl Cardiol. 2018 Oct;25(5):1692-1704. doi: 10.1007/s12350-017-0841-z. Epub 2017 Mar 8.

Abstract

Background: We studied the impact of simultaneous dual-isotope acquisition on 123I/99mTc mismatch assessment using two CZT cameras (DNM 530c, GE Healthcare and DSPECT, Biosensors International).

Methods: We used an anthropomorphic torso phantom (respectively filled with a solution of 123I alone, 99mTc alone, and a mixture of 123I and 99mTc) and its cardiac insert with two defects mimicking two matched and mismatched defects. Mismatch extent and reconstructed image contrast were evaluated.

Results: The acquisition mode (single vs dual) significantly impacted (i) 99mTc (but not 123I) reconstructed segmental activities using both camera (P < .001), and (ii) image contrast (using 123I and DNM 530c, P < .0001; and using both 123I and 99mTc with DSPECT, P < .0001). However, the defect and mismatch size were not impacted by the type of acquisition. With both DNM 530c and DSPECT, Lin's concordance correlation coefficient and Bland-Altman analysis demonstrated an almost perfect concordance and agreement between single- and simultaneous dual-isotope segmental activity (123I and 99mTc).

Conclusions: This study found no impact of the acquisition mode (single vs dual) or the type of camera (DSPECT vs DNM 530c) on 123I and 99mTc defect size and mismatch, providing a new step toward simultaneous dual-isotope acquisition for combined innervation and perfusion assessment.

Keywords: CZT; DNM 530c; DSPECT; dual isotope; mIBG; mismatch.

MeSH terms

  • Cadmium
  • Heart / diagnostic imaging*
  • Humans
  • Iodine Radioisotopes
  • Phantoms, Imaging*
  • Radioactive Tracers
  • Technetium
  • Tellurium
  • Tomography, Emission-Computed, Single-Photon / instrumentation
  • Tomography, Emission-Computed, Single-Photon / methods*
  • Zinc

Substances

  • CdZnTe
  • Iodine Radioisotopes
  • Radioactive Tracers
  • Cadmium
  • Technetium
  • Iodine-123
  • Zinc
  • Tellurium