Orthotopic liver transplantation for primary sclerosing cholangitis

Ann Surg. 1988 Jan;207(1):21-5. doi: 10.1097/00000658-198801000-00005.


The incidence or diagnostic rate of sclerosing cholangitis is increasing. Because of the lack of effective medical or surgical therapy for patients with end-stage liver disease and sclerosing cholangitis, results with orthotopic liver transplantation were examined. The results of 55 consecutive liver replacements for this disease were reviewed. The 1- and 2-year actuarial survival rates are 71% and 57%, respectively. Orthotopic liver transplantation for end-stage liver disease from sclerosing cholangitis has emerged as the most effective therapy.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenoma, Bile Duct / surgery
  • Adolescent
  • Adult
  • Cholangiography
  • Cholangitis / diagnostic imaging
  • Cholangitis / mortality
  • Cholangitis / surgery*
  • Female
  • Follow-Up Studies
  • Humans
  • Liver Neoplasms / surgery
  • Liver Transplantation*
  • Male
  • Middle Aged
  • Recurrence
  • Sclerosis
  • Time Factors