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. 2017 Mar 9;15(3):e2002050.
doi: 10.1371/journal.pbio.2002050. eCollection 2017 Mar.

All Biology Is Computational Biology

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Free PMC article

All Biology Is Computational Biology

Florian Markowetz. PLoS Biol. .
Free PMC article

Abstract

Here, I argue that computational thinking and techniques are so central to the quest of understanding life that today all biology is computational biology. Computational biology brings order into our understanding of life, it makes biological concepts rigorous and testable, and it provides a reference map that holds together individual insights. The next modern synthesis in biology will be driven by mathematical, statistical, and computational methods being absorbed into mainstream biological training, turning biology into a quantitative science.

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Carl von Linné, the Swedish botanist and father of taxonomy, would be a computational biologist today.
Image credit: Nationalmuseum Stockholm.

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References

    1. Longo D.L. and Drazen J.M., Editorial Data Sharing, N Engl J Med 2016; 374:276–277 10.1056/NEJMe1516564 - DOI - PubMed
    1. Stevens Hallam, Life Out of Sequence: A Data-Driven History of Bioinformatics, The University of Chicago Press; 2013
    1. Alexandrov L. B. et al. Signatures of mutational processes in human cancers. Nature 2013. August 22; 500(7463): 415–421. 10.1038/nature12477 - DOI - PMC - PubMed
    1. Weber J.L. and Myers E.W.. Human whole-genome shotgun sequencing. Genome Res. 1997. May;7(5):401–9. - PubMed
    1. Flicek P. and Birney E. Sense from sequence reads: methods for alignment and assembly. Nat Methods. 2009. November;6(11 Suppl):S6–S12. 10.1038/nmeth.1376 - DOI - PubMed

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