DAI Another Way: Necroptotic Control of Viral Infection

Cell Host Microbe. 2017 Mar 8;21(3):290-293. doi: 10.1016/j.chom.2017.01.016.

Abstract

Interrogation of murine cytomegalovirus (MCMV)-encoded cell-death suppressors revealed that necroptosis functions as a trap door to eliminate virally infected cells. This crucial host defense pathway is orchestrated by the sensing of infection by DAI/ZBP-1, engagement of the kinase RIPK3, and subsequent membrane permeablization by the pseudokinase MLKL.

MeSH terms

  • Animals
  • Cell Death*
  • Cytomegalovirus / growth & development*
  • Cytomegalovirus Infections / immunology*
  • Glycoproteins / metabolism*
  • Mice
  • RNA-Binding Proteins
  • Receptor-Interacting Protein Serine-Threonine Kinases / metabolism*

Substances

  • Glycoproteins
  • RNA-Binding Proteins
  • Zbp1 protein, mouse
  • Receptor-Interacting Protein Serine-Threonine Kinases
  • Ripk3 protein, mouse