DAI Another Way: Necroptotic Control of Viral Infection

Jason W Upton; William J Kaiser

doi:10.1016/j.chom.2017.01.016

DAI Another Way: Necroptotic Control of Viral Infection

Cell Host Microbe. 2017 Mar 8;21(3):290-293. doi: 10.1016/j.chom.2017.01.016.

Authors

Jason W Upton¹, William J Kaiser²

Affiliations

¹ Department of Molecular Biosciences, LaMontagne Center for Infectious Disease, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA. Electronic address: upton@austin.utexas.edu.
² Department of Microbiology, Immunology, & Molecular Genetics, University of Texas Health Sciences Center at San Antonio, San Antonio, TX 78229, USA.

PMID: 28279333
DOI: 10.1016/j.chom.2017.01.016

Abstract

Interrogation of murine cytomegalovirus (MCMV)-encoded cell-death suppressors revealed that necroptosis functions as a trap door to eliminate virally infected cells. This crucial host defense pathway is orchestrated by the sensing of infection by DAI/ZBP-1, engagement of the kinase RIPK3, and subsequent membrane permeablization by the pseudokinase MLKL.

MeSH terms

Animals
Cell Death*
Cytomegalovirus / growth & development*
Cytomegalovirus Infections / immunology*
Glycoproteins / metabolism*
Mice
RNA-Binding Proteins
Receptor-Interacting Protein Serine-Threonine Kinases / metabolism*

Substances

Glycoproteins
RNA-Binding Proteins
Zbp1 protein, mouse
Receptor-Interacting Protein Serine-Threonine Kinases
Ripk3 protein, mouse