Trained Immunity: An Ancient Way of Remembering

Cell Host Microbe. 2017 Mar 8;21(3):297-300. doi: 10.1016/j.chom.2017.02.003.


The innate arm of the immune system has generally been regarded as primitive and non-specific and, in contrast to adaptive immunity, not to possess memory. Here we review the growing body of evidence that innate immunity has an important capacity to adapt, a de facto innate immune memory (also termed trained immunity), and this provides broad protection against infections.

Keywords: cytokines; infections; innate immune memory; trained immunity; vertebrate immunity.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Immunity, Innate*
  • Immunologic Memory*