A Microbiome Foundation for the Study of Crohn's Disease

Dirk Gevers; Subra Kugathasan; Dan Knights; Aleksandar D Kostic; Rob Knight; Ramnik J Xavier

doi:10.1016/j.chom.2017.02.012

A Microbiome Foundation for the Study of Crohn's Disease

Cell Host Microbe. 2017 Mar 8;21(3):301-304. doi: 10.1016/j.chom.2017.02.012.

Authors

Dirk Gevers¹, Subra Kugathasan², Dan Knights³, Aleksandar D Kostic⁴, Rob Knight⁵, Ramnik J Xavier⁶

Affiliations

¹ Janssen Human Microbiome Institute at Janssen Research and Development LLC, Cambridge, MA 02142, USA. Electronic address: dgevers3@its.jnj.com.
² Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Emory University, Atlanta, GA 30322, USA.
³ Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55108, USA; BioTechnology Institute, University of Minnesota, St. Paul, MN 55108, USA.
⁴ Research Division, Joslin Diabetes Center, Boston, MA 02215, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
⁵ BioFrontiers Institute, University of Colorado, Boulder, CO 80309, USA; Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA; Howard Hughes Medical Institute, Boulder, CO 80309, USA.
⁶ Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Abstract

Our 2014 study published in Cell Host & Microbe, "The Treatment-Naive Microbiome in New-Onset Crohn's Disease," was designed to improve our understanding of the microbiome's role in Crohn's disease by studying a unique, well-suited cohort and sample set. This commentary provides a hindsight perspective of this original study as well as future outlook.

MeSH terms

Crohn Disease / etiology*
Crohn Disease / microbiology*
Crohn Disease / pathology
Gastrointestinal Microbiome*
Humans
Microbiota*

Abstract

MeSH terms

Grants and funding