Dengue hemorrhagic fever is shown to correlate with secondary infection with a virus serotype different from the previous infection. However, only a small fraction of secondary infections leads to hemorrhagic fever. A recent Science paper suggests that the fucosylation state and isotype of IgGs elicited in patients may enhance disease severity.
Keywords: IgG; dengue; dengue hemorrhagic fever; enhancement of disease; fucosylation of IgG; platelet depletion.
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