Unsweetened IgG Is Bad for Dengue Patients

Cell Host Microbe. 2017 Mar 8;21(3):312-314. doi: 10.1016/j.chom.2017.02.011.

Abstract

Dengue hemorrhagic fever is shown to correlate with secondary infection with a virus serotype different from the previous infection. However, only a small fraction of secondary infections leads to hemorrhagic fever. A recent Science paper suggests that the fucosylation state and isotype of IgGs elicited in patients may enhance disease severity.

Keywords: IgG; dengue; dengue hemorrhagic fever; enhancement of disease; fucosylation of IgG; platelet depletion.

Publication types

  • Comment

MeSH terms

  • Antibodies, Viral
  • Coinfection
  • Dengue / virology*
  • Dengue Virus / immunology*
  • Humans
  • Immunoglobulin G
  • Severe Dengue / virology

Substances

  • Antibodies, Viral
  • Immunoglobulin G