West African Ebola Virus Strains: Unstable and Ready to Invade?

Christopher F Basler

doi:10.1016/j.chom.2017.02.017

West African Ebola Virus Strains: Unstable and Ready to Invade?

Cell Host Microbe. 2017 Mar 8;21(3):316-318. doi: 10.1016/j.chom.2017.02.017.

Author

Christopher F Basler¹

Affiliation

¹ Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. Electronic address: cbasler@gsu.edu.

PMID: 28279342
DOI: 10.1016/j.chom.2017.02.017

Abstract

Recent studies demonstrate that the Ebola virus glycoprotein (GP) acquired an A82V change during the West Africa epidemic and that this change altered the capacity of GP to be activated by host factors, enhancing infection of human cells. How this may alter the outcome of disease remains to be determined.

Publication types

Comment

MeSH terms

Africa, Western / epidemiology
Ebolavirus*
Epidemics
Glycoproteins
Hemorrhagic Fever, Ebola / epidemiology*
Humans

Substances

Glycoproteins