Testing the Amyloid Hypothesis with a Humanized AD Mouse Model

Michelle K Cahill; Eric J Huang

doi:10.1016/j.neuron.2017.02.044

Testing the Amyloid Hypothesis with a Humanized AD Mouse Model

Neuron. 2017 Mar 8;93(5):987-989. doi: 10.1016/j.neuron.2017.02.044.

Authors

Michelle K Cahill¹, Eric J Huang²

Affiliations

¹ Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA 94143, USA.
² Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA 94143, USA; Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA; Division of Neuropathology Research, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94143, USA; Pathology Service 113B, Veterans Administrations Medical Center, San Francisco, CA 94121, USA. Electronic address: eric.huang2@ucsf.edu.

PMID: 28279360
DOI: 10.1016/j.neuron.2017.02.044

Abstract

In this issue of Neuron, Espuny-Camacho et al. (2017) generate a humanized Alzheimer's disease (AD) model that reveals species-specific vulnerability of human neurons to AD pathology. This model provides key insights for disease mechanism and therapeutic discovery for AD.

Keywords: Alzheimer’s disease; amyloid plaque; induced pluripotent stem cells (iPSCs); mouse model; neurofibrillary tangle; transplantation.

Publication types

Review

MeSH terms

Alzheimer Disease / metabolism
Alzheimer Disease / pathology*
Amyloid / metabolism*
Amyloid beta-Peptides / metabolism*
Animals
Disease Models, Animal
Humans
Neurons / metabolism*
Neurons / pathology
tau Proteins / metabolism*

Substances

Amyloid
Amyloid beta-Peptides
tau Proteins

Grants and funding

I01 RX002133/RX/RRD VA/United States