Transduodenal-transpapillary endopancreatic surgery with a rigid resectoscope: experiments on ex vivo, in vivo animal models and human cadavers

Surg Endosc. 2017 Oct;31(10):4131-4135. doi: 10.1007/s00464-017-5465-5. Epub 2017 Mar 9.


Background: Surgery for chronic pancreatitis is afflicted with high morbidity. A novel transduodenal-transpapillary endopancreatic resection (EPR) may provide a less invasive alternative approach.

Materials and methods: After laparoscopic duodenotomy the papilla was dilated and accessed with a rigid resectoscope. A resection of pancreatic head tissue was performed from inside the organ. First, the feasibility and resection volume were assessed in bovine pancreas. Bleeding and intraoperative complications were evaluated in an acute in vivo pig model. Finally, the total laparoscopic approach was tested in human cadavers.

Results: EPR was feasible in 6/6 bovine and 5/6 porcine pancreases; in one case the papilla could not be located. The resected surface accounted for 30 (23-39)% of the total pancreatic surface and the resection volume was 14.2 (9-25) cm3. In vivo blood loss was minimal [10 (5-20) ml]. The operating time for EPR was 84 (75-110) min in all cadavers.

Conclusion: The EPR technique is feasible and provides a resection comparable with duodenum-preserving pancreatic head resection (DPPHR). Given the reduced surgical trauma, EPR may emerge as a minimally invasive alternative to DPPHR.

Keywords: Minimally invasive pancreatic surgery; Pancreatic resection; Transpapillary resection.

MeSH terms

  • Ampulla of Vater / surgery
  • Animals
  • Blood Loss, Surgical
  • Cadaver
  • Cattle
  • Dilatation
  • Duodenum / surgery*
  • Endoscopy, Digestive System / methods*
  • Feasibility Studies
  • Female
  • Humans
  • Intraoperative Complications
  • Laparoscopy / methods*
  • Male
  • Models, Animal
  • Operative Time
  • Pancreas / surgery*
  • Pancreatectomy / methods*
  • Pancreatitis, Chronic / surgery*
  • Sus scrofa
  • Swine