Moving towards totipotency without a single miR-acle

Cell Res. 2017 May;27(5):600-601. doi: 10.1038/cr.2017.30. Epub 2017 Mar 10.


Totipotency is the ability of a single cell to form an entire embryo, including extraembryonic tissues, an ability we have yet to recapitalize, in vitro. In a recent paper published in Science, Choi et al. showed that pluripotent stem cells lacking microRNA miR-34a, have an expanded cell fate potential allowing differentiation into not only embryonic but also extraembryonic lineages.

Publication types

  • Comment

MeSH terms

  • Cell Differentiation
  • MicroRNAs*
  • Pluripotent Stem Cells*


  • MicroRNAs