Effects of Aging in Dry Eye

Int Ophthalmol Clin. Spring 2017;57(2):47-64. doi: 10.1097/IIO.0000000000000170.


Dry eye affects millions of people worldwide and causes eye well recognized risk factors for dry eye. Anatomical and inflammation-induced age-related changes affect all components of the lacrimal gland functional unit, inclusive of lacrimal gland, conjunctiva, meibomian gland and compromise ocular surface health. There is increased evidence that inflammation plays a role in dry eye. This review will summarize the current knowledge about aging and dry eye, inclusive of lessons learned from animal models and promising therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / physiology*
  • Animals
  • Disease Models, Animal
  • Dry Eye Syndromes / physiopathology*
  • Dry Eye Syndromes / therapy
  • Humans
  • Oxidative Stress / physiology
  • Risk Factors
  • T-Lymphocytes / physiology