Inside the Chamber of Secrets of the Type III Secretion System

Cell. 2017 Mar 9;168(6):949-951. doi: 10.1016/j.cell.2017.02.028.


The bacterial type III secretion system is a specialized machine that injects effectors into eukaryotic cells to manipulate the host cell physiology. In this issue of Cell, Hu et al. use cryo-electron tomography to reveal an unprecedented level of details regarding the architecture of this machine and the conformational changes that occur during its assembly.

Publication types

  • Comment

MeSH terms

  • Bacterial Proteins
  • Electron Microscope Tomography*
  • Humans
  • Type III Secretion Systems*


  • Bacterial Proteins
  • Type III Secretion Systems