The effects of obesity on lung volumes and oxygenation

Respir Med. 2017 Mar:124:15-20. doi: 10.1016/j.rmed.2017.01.004. Epub 2017 Jan 18.

Abstract

Introduction: Obesity can cause hypoxemia by decreasing lung volumes to where there is closure of lung units during normal breathing. Studies describing this phenomenon are difficult to translate into clinical practice. We wanted to determine the lung volume measurements that are associated with hypoxemia in obese patients, and explore how we could use these measurements to identify them.

Methods: We collected pulmonary function test results and arterial blood gas data on 118 patients without obstruction on pulmonary function testing. We included only patients with normal chest imaging and cardiac testing within one year of the pulmonary function test, to exclude other causes of hypoxemia.

Results: We found that as BMI increases, the mean paO2, ERV % predicted, and ERV/TLC decrease (BMI 20-30 kg/m2: paO2=90±8 mmHg, ERV% predicted 112±50, ERV/TLC (%) 19.7±6.5; BMI 30-40 kg/m2: paO2=84±10 mmHg, ERV% predicted 84±40 ERV/TLC(%) 13.6±7.6; BMI>40 kg/m2: paO2 78 ±12 mmHg, ERV% predicted 64±27 ERV/TLC(%) 11.4±5.8, ANOVA p<0.001). The A-a gradient increases as BMI increases (r=0.42, p<0.001). This correlation was stronger in men (r=0.54) than in women (r=0.35). The paO2 is lower in patients with a low ERV than in those with a normal ERV (p<0.001). In a multivariate linear regression, only the ERV/TLC predicted (%), age, and BMI were associated with oxygenation (r2 for A-a gradient =0.28, p=0.036).

Conclusions: In obese patients without cardiopulmonary disease, oxygen levels decrease as BMI increases. This effect is associated with the obesity-related reduction in ERV and is independent of hypoventilation.

Keywords: Atelectasis; Pulmonary function tests; Pulmonary gas exchange.

MeSH terms

  • Adult
  • Blood Gas Analysis / instrumentation
  • Body Mass Index
  • Expiratory Reserve Volume / physiology
  • Female
  • Functional Residual Capacity / physiology
  • Humans
  • Hypoxia / complications
  • Hypoxia / physiopathology*
  • Lung / metabolism
  • Lung / physiopathology*
  • Lung Volume Measurements / methods*
  • Male
  • Middle Aged
  • Obesity / complications*
  • Obesity / ethnology
  • Obesity / physiopathology
  • Oxygen / blood
  • Pulmonary Gas Exchange / physiology
  • Respiration
  • Respiratory Function Tests / methods
  • Spirometry
  • Tidal Volume / physiology*

Substances

  • Oxygen