Autoimmune limbic encephalitis with anti-contactin-associated protein-like 2 antibody secondary to pembrolizumab therapy

Michael P Brown; Pravin Hissaria; Amy Hc Hsieh; Christopher Kneebone; Wilson Vallat

doi:10.1016/j.jneuroim.2016.12.016

Autoimmune limbic encephalitis with anti-contactin-associated protein-like 2 antibody secondary to pembrolizumab therapy

J Neuroimmunol. 2017 Apr 15:305:16-18. doi: 10.1016/j.jneuroim.2016.12.016. Epub 2017 Jan 18.

Authors

Michael P Brown¹, Pravin Hissaria², Amy Hc Hsieh³, Christopher Kneebone⁴, Wilson Vallat⁵

Affiliations

¹ Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia. Electronic address: MichaelP.Brown@sa.gov.au.
² Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia. Electronic address: Pravin.Hissaria@sa.gov.au.
³ Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia. Electronic address: hsinchiehamy.hsieh@sa.gov.au.
⁴ Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia. Electronic address: Chris.Kneebone@sa.gov.au.
⁵ Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia. Electronic address: Wilson.vallat@sa.gov.au.

PMID: 28284337
DOI: 10.1016/j.jneuroim.2016.12.016

Abstract

Immune checkpoint inhibitors such as Pembrolizumab are used to restore antitumour immune response. It is important to be vigilant of immune mediated adverse events related to such therapy. We report a case of autoimmune limbic encephalitis with Contactin-Associated Protein-like 2 (CASPR2) antibody secondary to Pembrolizumab therapy for metastatic melanoma.

Publication types

Case Reports

MeSH terms

Aged
Antibodies, Monoclonal, Humanized / adverse effects*
Autoantibodies / therapeutic use*
Autoimmune Diseases / diagnostic imaging
Autoimmune Diseases / immunology*
Autoimmune Diseases / therapy*
Humans
Limbic Encephalitis / diagnostic imaging
Limbic Encephalitis / immunology*
Limbic Encephalitis / therapy*
Magnetic Resonance Imaging
Male
Melanoma / immunology
Melanoma / therapy
Membrane Proteins / immunology*
Nerve Tissue Proteins / immunology*

Substances

Antibodies, Monoclonal, Humanized
Autoantibodies
CNTNAP2 protein, human
Membrane Proteins
Nerve Tissue Proteins
pembrolizumab

Supplementary concepts

Autoimmune limbic encephalitis