Incidence and Causes of Intentional Fetal or Neonatal Demise in Twin-Twin Transfusion Syndrome

Fetal Diagn Ther. 2018;43(1):19-25. doi: 10.1159/000461580. Epub 2017 Mar 11.

Abstract

Introduction: The aim of this study is to evaluate the incidence and causes of intentional fetal and neonatal demise in twin-twin transfusion syndrome (TTTS).

Material and methods: All TTTS pregnancies managed at our centre between 2000 and 2014 were included. We evaluated incidence and causes of intentional fetal/neonatal demise, defined as termination of pregnancy, selective fetal reduction, or withdrawal of neonatal intensive care.

Results: Intentional fetal/neonatal demise occurred in 9.8% (110/1,122) of fetuses and was due to termination of pregnancy (2.2%), selective fetal reduction (4.2%), or withdrawal of neonatal intensive care (3.4%). Reasons for termination of pregnancy included complications of laser treatment (72.0%), severe fetal anomaly (20.0%), and unwanted pregnancy (8.0%). Reasons for selective fetal reduction were technical difficulties to perform laser surgery (51.1%), fetal complications (38.3%), and parental preference for fetal reduction rather than laser treatment (10.6%). Reasons for withdrawal of neonatal intensive care treatment were severe cerebral injury (47.4%), severe pulmonary complications (15.8%), birth asphyxia (5.3%), multiple complications of TTTS and/or prematurity combined (21.1%), or other (10.5%).

Conclusions: Intentional fetal or neonatal demise in TTTS occurs frequently and is often due to complications after laser surgery and/or severe (cerebral) injury in affected fetuses or neonates.

Keywords: Cerebral injury; Fetoscopic laser therapy; Selective fetal reduction; Termination of pregnancy; Twin-twin transfusion syndrome; Withdrawal of neonatal intensive care.

Publication types

  • Twin Study

MeSH terms

  • Female
  • Fetal Death
  • Fetofetal Transfusion / diagnosis
  • Fetofetal Transfusion / mortality
  • Fetofetal Transfusion / therapy*
  • Fetoscopy / adverse effects*
  • Fetoscopy / mortality
  • Humans
  • Incidence
  • Infant
  • Infant Mortality
  • Infant, Newborn
  • Intensive Care, Neonatal*
  • Laser Therapy / adverse effects*
  • Laser Therapy / mortality
  • Male
  • Netherlands / epidemiology
  • Pregnancy
  • Pregnancy Reduction, Multifetal / adverse effects*
  • Pregnancy Reduction, Multifetal / mortality
  • Risk Factors
  • Time Factors
  • Treatment Outcome
  • Withholding Treatment*