Intensive care medicine research agenda on cardiac arrest

Intensive Care Med. 2017 Sep;43(9):1282-1293. doi: 10.1007/s00134-017-4739-7. Epub 2017 Mar 11.


Over the last 15 years, treatment of comatose post-cardiac arrest patients has evolved to include therapeutic strategies such as urgent coronary angiography with percutaneous coronary intervention (PCI), targeted temperature management (TTM)-requiring mechanical ventilation and sedation-and more sophisticated and cautious prognostication. In 2015, collaboration between the European Resuscitation Council (ERC) and the European Society for Intensive Care Medicine (ESICM) resulted in the first European guidelines on post-resuscitation care. This review addresses the major recent advances in the treatment of cardiac arrest, recent trials that have challenged current practice and the remaining areas of uncertainty.

Keywords: Advanced life support; Basic life support; Cardiac arrest; Cardiopulmonary resuscitation; Post-resuscitation care; Prognostication.

Publication types

  • Review

MeSH terms

  • Biomedical Research
  • Cardiopulmonary Resuscitation / education
  • Cardiopulmonary Resuscitation / methods*
  • Coma / therapy
  • Coronary Angiography / methods*
  • Critical Care
  • Humans
  • Hypothermia, Induced / methods*
  • Neuroprotective Agents / therapeutic use
  • Out-of-Hospital Cardiac Arrest / diagnosis
  • Out-of-Hospital Cardiac Arrest / mortality
  • Out-of-Hospital Cardiac Arrest / therapy*
  • Outcome Assessment, Health Care
  • Percutaneous Coronary Intervention / methods
  • Randomized Controlled Trials as Topic
  • Respiration, Artificial / methods
  • Time-to-Treatment


  • Neuroprotective Agents