Antimicrobial activity of crude fractions and morel compounds from wild edible mushrooms of North western Himalaya

Microb Pathog. 2017 Apr;105:356-360. doi: 10.1016/j.micpath.2017.03.005. Epub 2017 Mar 7.


The antimicrobial properties of morel compounds from wild edible mushrooms (Morchella esculenta and Verpa bohemica) from Kashmir valley was investigated against different clinical pathogens. The butanol crude fraction of most popular or true morel M. esculenta showed highest 19 mm IZD against E.coli while as same fraction of Verpa bohemica exhibited 15 mm IZD against same strain. The ethyl acetate and butanol crude fractions of both morels also exhibited good antifungal activity with highest IZD shown against A. fumigates. The three morel compounds showed quite impressive anti bacterial and fungal activities. The Cpd 3 showed highest inhibitory activity almost equivalent to the synthetic antibiotics used as control. The MIC/MBC values revealed the efficiency of isolated compounds against the pathogenic strains. In the current study significant inhibitory activity of morel compounds have been obtained paying the way for their local use from ancient times.

Keywords: Antimicrobial activity; Inhibition mushrooms; Morels; Pathogens.

MeSH terms

  • Acetates / chemistry
  • Agaricales / chemistry*
  • Anti-Infective Agents / chemistry*
  • Anti-Infective Agents / isolation & purification
  • Anti-Infective Agents / pharmacology*
  • Antifungal Agents / pharmacology
  • Ascomycota / chemistry
  • Aspergillus fumigatus / drug effects
  • Butanols / chemistry
  • Escherichia coli / drug effects
  • Fungi / drug effects
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Microbial Sensitivity Tests / methods
  • Phytochemicals / chemistry
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*


  • Acetates
  • Anti-Infective Agents
  • Antifungal Agents
  • Butanols
  • Phytochemicals
  • Plant Extracts
  • ethyl acetate