Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy

Mitochondrion. 2017 Sep;36:60-65. doi: 10.1016/j.mito.2017.03.002. Epub 2017 Mar 10.


Peripapillar and nerve head vessel density (VD) was measured in 10 patients affected by Dominant optic atrophy (DOA) using optical coherence tomography angiography (OCT-A) and compared to the measurements of 15 age- and gender-matched controls. DOA patients showed VD reduction, mostly in the temporal and inferotemporal peripapillary sectors, according to the preferential involvement of the papillomacular bundle. Despite poor best-corrected visual acuity (BCVA), OCT-A revealed good repeatability. VD correlated with functional (mean deviation of visual field and BCVA) and structural (retinal nerve fiber layer thickness) parameters and could be a non-invasive, quantitative tool for the monitoring of the disease and of the therapeutic approaches.

Keywords: DOA; Dominant optic atrophy; Inherited mitochondrial optic neuropathies; Optical coherence tomography angiography; Vessel density.

Publication types

  • Evaluation Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Angiography / methods*
  • Atrophy / diagnostic imaging*
  • Atrophy / pathology
  • Blood Vessels / diagnostic imaging*
  • Blood Vessels / pathology
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Optic Atrophy, Autosomal Dominant / diagnostic imaging*
  • Optic Atrophy, Autosomal Dominant / pathology
  • Optic Disk / diagnostic imaging*
  • Optic Disk / pathology
  • Prospective Studies
  • Tomography, Optical Coherence / methods*
  • Young Adult