Epigenetics of kidney disease

Cell Tissue Res. 2017 Jul;369(1):75-92. doi: 10.1007/s00441-017-2588-x. Epub 2017 Mar 13.

Abstract

DNA methylation and histone modifications determine renal programming and the development and progression of renal disease. The identification of the way in which the renal cell epigenome is altered by environmental modifiers driving the onset and progression of renal diseases has extended our understanding of the pathophysiology of kidney disease progression. In this review, we focus on current knowledge concerning the implications of epigenetic modifications during renal disease from early development to chronic kidney disease progression including renal fibrosis, diabetic nephropathy and the translational potential of identifying new biomarkers and treatments for the prevention and therapy of chronic kidney disease and end-stage kidney disease.

Keywords: Chronic kidney disease; Diabetes; Epigenetic therapy; Epigenetics; Kidney.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA Methylation*
  • Epigenesis, Genetic*
  • Fibrosis
  • Humans
  • Kidney / metabolism*
  • Kidney / pathology
  • Kidney Failure, Chronic / metabolism*
  • Kidney Failure, Chronic / pathology
  • Renal Insufficiency, Chronic / metabolism*
  • Renal Insufficiency, Chronic / pathology